Aims. The clinical and radiograph study aimed to assess distribution and types of pulp-dentin defensive reactions related to localisation, depth, progression (acute or chronic) of dental caries in 15-35 age patients. Matherial and methods. Caries were assessed in 128 patients divided in two groups: 15-25 age and 26-35 age. Dental caries were divided in incipient, cavitary superficial, medium and deep lesions. Results were recorded and processed in Microsoft Excel. The final results suggest that type and intensity of defensive pulp-dentinal reactions depend on cavitation stage, localisation, depth, progression and age group. Conclusion. Pulp-dentine complex presents a reactive potential against bacterial factors from dental caries, expressed through remineralization processes, dentine hipermineralization, neodentinogenesis, volume reduction of pulp room and pulpal calcifications.