The diabetes manifests itself through alterations of lipid, glucose and protein metabolism. Characteristics of inflammatory response in the periodontal disease for the diabetic ground consist of the increase of LDL level with atherom forming, deposits of proteins and lipids at the periodontal level, changes of PMN functions with alteration of chemotactism, adherence and efficiency of phagocitosis on the background of characteristic exaggerated immune response. Enzymes like colagenases, elastases and gelatinases are responsible of the connective and osseous tissue lyses in diabetes. Although there were not signaled modifications of IgG, IgA and IgM at diabetic patients, it was identified instead a marker protein IA-2g at patients with immune-dependant diabetes, in combination with other 2 marker proteins IA-2 and GAD 65. The accelerated immune responses, supposed of being connected of deformation of ACE (advanced glycation end-products) were indirectly sustained of observations on the significantly higher levels of PGE2 and IL-1 in crevicular fluids.
Keywords:- diabetes
- INFLAMMATORY MARKERS
- PERIODONTAL DISEASE