Nitrous oxide/oxygen sedation has been used for over 160 years to assist in the management of pain and anxiety. It is commonly used in many dental specialties and other health disciplines have also benefitted. In many instances, patients present to medical and dental offices with both pain and anxiety. It is necessary to manage both, since they are interrelated. Nitrous oxide and oxygen sedation can assist patients with their pain and anxiety, and can be employed safely and effectively with minimal concerns. Its use is currently enjoying tremendous growth worldwide.