Gingival overgrowth is a pathological manifestation related to some systemic diseases or to the administration of certain drugs, such as calcium channel blockers (nifedipine).
The aim of this study was to determine the role of CTGF, Cyr61, ornithine decarboxylase and NF-kB cell growth factors in nifedipine-induced GINGIVAL OVERGROWTH. A 50mg/body weight dose of nifedipine (Adalat) was administered to rats, by subcutaneous injections 6 days a week for 45 days. The collected tissues were examined both microscopically and immunohistochemically.
The identified histological changes consisted in epithelial hyperplasia, enlarged gingival lamina propria with or without collagen deposition in the subepithelial lamina propria, decreased cellularity and rich microvascularization. The qualitative assessment of growth factors suggested that, in the development of the GO-associated tissue, changes in these factors are expressed in excess or inhibited (ornithine decarboxylase), as compared to the control tissues.
- GINGIVAL OVERGROWTH
- GROWTH FACTORS
- nifedipine