Leptin is a protein involved in the adjustment of the satiety apetite equilibrium. Neuroleptics are drugs used as anti-psychotics, their secondary effect being related to weight increase. For the time being, the mechanism through which the neuroleptics induce such an effect is not wholly elucidated, even if some relation is to be mentioned between the levels of circulating leptin, administration of neuroleptics and weight increase. The aim of the present study was to evidence the salivary leptin levels registered during neuroleptics administration.
Materials and Method. Salivary leptin was determined by the ELISA technique, on two groups of rats treated with Chlorpromazine and Risperidone for 4 weeks. Results. The salivary leptin levels increased after the administration of the two neuroleptics. Conclusions.
The treatment with Chlorpromazine and Risperidone induces an increase in the salivary leptin levels.
- salivary leptin