Special needs individuals are children or adults prevented by a physical or mental condition permitting their full participation to the normal range of activities of their age groups. They usually exhibit high orthodontic treatment needs because of an increased prevalence and severity of malocclusions. These conditions often require a coordinated craniofacial orthodontic and surgical treatment in a team setting, to achieve optimal outcome. Orthodontic treatments for patients born with facial differences tend to be more complex than ordinary orthodontics. This multidisciplinary treatment often starts from birth and extends up to the late teen years. The young patient may require treatment by multiple specialists, including a craniofacial surgeon, pediatrician, geneticist, neurosurgeon, ENT, speech and language therapist, pediatric dentist, oral surgeon and prosthodontist. The objective of this paper is to summarize protocols of orthodontic treatment and to present various orthodontic management protocols regarding the children with special needs.