Orthodontic tooth movement results from the response of the periodontal tissue to orthodontic forces, which leads to modeling and remodeling of the surrounding alveolar bone. The endocrine system is responsible for hormonal secretion, being closely related to the central nervous system, as it diversifies its functions through the hypothalamus and pituitary glands. It controls physiological processes and maintains homeostasis. The neuroendocrine system is responsible for adaptation to environmental changes. Also, the nervous system may provide a correct organic response, of primary type, with the release of neurotransmitters or, if the stimulus prevails, the endocrine system secretes hormones. This is especially important in dentistry because many of the patients attending dental clinics face stressful situations. Awareness is therefore necessary on the risks and difficulties that may arise during the dental and orthodontic management of patients with endocrine disorders and most common oral manifestations.