Mobile gnatoprosthetic devices solve the problems caused by the morpho-functional recovery of the stomatognate system, even if their application affects the tissues contacting them. In the case in which the injuries produced to the mucous membrane of the prosthetic field exceed the physiological tolerance, various pathological modifications may occur, generically defined as paraprosthetic stomatopathies. Paraprosthetic stomatopathies and their occurrence are varied and their complexity is insufficiently known. The problem of etiopathogeneicity is still to be elucidated, as to the series of unknown quantities caused by the interference of the numerous systemic and local factors, whose individual influence is difficult to state. Several studies have indicated that the lesions of prosthetic stomatites are associated with the detected presence of Candida species, while other factors, such as local traumatisms, scarce hygiene of the prostheses, systemic maladies and immune deficiencies may be also involved.