People have always come into contact with nanoparticles of various chemical structures that entered the human organism by different – respiratory, ingestive, transdermal – paths. The small size of these particles makes them able to penetrate the cell walls; however, their effects and mechanisms of action are far from being known. The benefits of nanoparticles in medicine, as well as their potential adverse effects, depend on their localization and accumulation in the body. In this work, titanium dioxide (TiO2) anatase nanoparticles were characterized using various techniques: dynamic light scattering (DLS), zeta potential, transmission electron microscopy (TEM) and
energy dispersive spectroscopy (EDAX). The size of the TiO2 nanoparticles dispersed in different aqueous solutions was around 30 nm, and the zeta potential revealed their agglomeration tendency. Hemolysis test indicates nanoparticle concentrations over 400 μg/mL, inducing increased hemolysis effects (>10%).
- aggregation
- hemolysis
- TiO2 nanoparticles
- zeta potential