Authors: Maryna ANTONENKO, Valentyn REVICH, Nadia KOLESOVA, Dimitrii MALY, Serghei PALAMARCHUK


The urgency of the study is due to the fact that, despite the discussions, in the literature, on the main components of the pathogenesis of generalized periodontitis (GP), the generally accepted concept describing the development of periodontal pathology in young people is not clearly formulated. The aim is to specify the role of energy metabolism disorders in the development of functional changes and the clinical symptoms of inflammatory and destructive periodontal diseases in young people. Materials and methods. Complex clinical, laboratory and morphological studies devoted to the changes in energy metabolism in patients with generalized periodontitis (GP) of the 1st degree have been carried out. The activity of a complex of limiting breathing enzymes, glycolysis, a pentose cycle and terminal oxidation has been studied histochemically, according to the generally accepted methods. Morphological studies are performed on incisive gum biopsies in 30 patients with GP. In 13 patients, the periodontal pathology was in the exacerbation stage. The control group consisted of 7 healthy individuals. All subjects had ages between 19 and 30 years. The results revealed changes in the energy exchange in the gums for GP, suggesting that the development of clinical manifestations causes important violation in the energy supply of periodontal tissues, and in the development of tissue hypoxia signs. Based on the obtained data, an early prophylactic and therapeutic application in the complex therapy of drugs of metabolitotropic types of action: antihypoxants and antioxidants, may be recommended. A purposeful use of antihypoxants and antioxidants will allow to some extent to balance the disturbed energy homeostasis of the periodontal tissues, the course of compensatory and adaptive processes occurring in them, and will help prevent the progression of clinical symptoms of the disease. Conclusions. The basis of pathological changes in periodontal tissues causing the development of GP in young people is restructuration of energetic metabolism, with the transition to the less sensitive to lack of oxygen ways of generating energy, and the manifestation of tissue hypoxia signs. The clinical symptoms of GF develop against the background of metabolic pathways of energy formation, which manifests itself as a decrease inthe activity of tissue enzymes, the pentose cycle and terminal oxidation, while increasing the activity of enzymes glycolysis. Based on the obtained data, rationally recommended in the complex therapy of GP in young people is an early prophylactic and therapeutic use of pharmacological preparations with metabolitotropic type of action – antihypoxants and antioxidants.

  • energy metabolism.
  • inflammation
  • periodontal tissue