Introduction. Dental materials used in dental practice interact with the humid environment of the oral cavity, causing adverse local reactions which depend on their pharmacological properties and also on the immunological status of the subject.The aim of the study is to update the data reported in the literature, related to the impact of dental materials upon oral mucosa and skin. Materials and methods. The main sources for selecting relevant articles were PubMed, Web of Science and Embase. Results and disscusion. According to data published in the literature, the incidence of adverse reactions is relatively low, the most commonly involved materials being the metals and residual monomers responsible for type IV allergic reactions identified by patch skin testing. Conclusions. The impact of dental materials on the cutaneous-mucosal structure is not fully elucidated, which is why further in-depth studies in the field are required, especially regarding the prophylactic etiopathogenetic mechanisms. The low prevalence of these types of reactions recommends the global implementation of a single standardized reporting and monitoring system, as model’s efficiency has already been demonstrated in several countries.
Keywords:- adverse
- allergic
- dental materials
- idiosyncratic reactions
- oral mucosa
- patch testing
- toxic