Diabetes mellitus has a major impact on metabolism, inducing many complications and contributing to increased mortality. Such complications often represent complex disorders, such as the diabetic foot, one of the major causes of non-traumatic lower limb amputation. Bone turnover and skeletal integrity can be affected in diabetes, with diabetic bone disease as a long-standing complication of it. Alveolar bone loss is one of the main features of periodontal disease, and diabetes is one of the risk factors for this condition. The present review provides complex, up-to-date information on possible common pathogenic ways related to bone turnover in these two chronic conditions, and also on the direct link between persistent hyperglycaemia, inflammation and alveolar bone loss.
Keywords:- bone turnover.
- diabetes
- diabetic foot
- PERIODONTAL DISEASE