Authors: Andriy BAMBULIAK, Nataliia KUZNIAK, Valentyna HONCHARENKO, Marianna OSTAFIYCHUK, Alina PALAMAR


Introduction. One of the priorities of modern surgical dentistry is the development of new effective methods for the treatment of fractures of the facial skeleton, which is associated with a significant increase in injuries of the maxillofacial area and the complexity of their treatment, among which the first is the fracture of the mandible. The aim of the study was to evaluate the clinical efficacy of using mesenchymal stromal cells of adipose tissue during osteosynthesis surgery in patients with mandibular fractures. Materials and methods. Osteosynthesis was performed in 56 patients according to the traditional method but, depending on the subgroup of the study, different osteoplastic materials were introduced into the fracture line.Results and discussion. Thus, it was found out that, in patients of subgroups 1B, the absence of pain at the final stage of postoperative observation was noted in 89.31% of persons, which was 1.2 and 1.3 times more than in subgroups 1A and 1C. Collateral edema was absent in 98.47% of the operated subgroups 1B, which exceeded the number of persons in subgroups 1A – 1.2 times, and in subgroups 1C – 1.4 times. The absence of hyperemia oral mucosa was determined in the final postoperative examination, in 92.37% of patients of subgroups 1B, which was 1.3 and 1.4 times more than the values in subgroups 1A and 1C. Conclusions. A comparative analysis of the clinical effectiveness of osteoplastic materials for increasing the volume of the alveolar bone during osteosynthesis on the mandible had the advantage of using the ”Kolopan – L” + MMSC-AT + PRP combination.

  • mesenchymal stromal cells
  • osteosynthesis
  • platelet-rich plasma