Introduction: Berberine, a benzylisoquinoline alkaloid found in a variety of medicinal plants, has a wide range of pharmacological characteristics. Berberine has diverse inhibitory effects on different bacteria, however a mark of its selectivity when using insilico methods is that the impact is very good with the maximal inhibitory concentration for Eikenella corrodens. Materials and methods: The STITCHv5.0 pipeline was primarily used for identifying drug-protein interactions; VirulentPred and VICMPred were used for elucidating the virulence property and functional class of the proteins. Results and discussion: Berberine interacts with the proteins included in cellular processes, metabolism, and pathogenicity. The pathogenic proteins attacked by medications were found in the cytoplasm, which would increase the potency of drug as to its antibacterial activity. Conclusions: A thorough understanding of the interactions between these medications and their antibacterial agents would increase the list of advantages of these treatments in therapeutic situations. To validate the true interactions between medicines and pathogen protein repertoires, more in vitro studies on a wide spectrum of infections are required.
Keywords:- bacteria
- berberine
- pathogenicity
- virulence