Introduction: Fusobacterium nucleatum is a periodontal pathogen and an anaerobic oral commensal that has been linked to a variety of human disorders. Triclosan has been used in toothpastes, cosmetics and antiseptic soaps, which are all examples of antibacterial and antifungal agents.To identify the virulence factors in Fusobacterium nucleatum targeted by triclosan through an insilico approach. Materials and methods: The STITCH v.5 pipeline12 was used to investigate drug interactions with the proteome of Fusobacterium nucleatum. VirulentPred and VICMPred were utilised to determine the virulence characteristic and functional class of the proteins using the pipeline. Results and discussion: Fusobacterium nucleatum interact with the proteins involved in cellular processes, metabolism and pathogenicity. Conclusions: A thorough understanding of the interactions between these medications and their antibacterial agents would increase the list of advantages such treatments show in therapeutic situations. To validate the true interactions between medicines and pathogen protein repertoires, more in vitro studies on a wide spectrum of infections are required.
Keywords:- Fusobacterium nucleatum
- proteins
- triclosan