Introduction. Both papillary squamous cell carcinomas (PSCC) and pancreatic solid pseudopapillary neoplasm (SPN) represent rare cases. PSCC is rare variant of SCC of the upper aerodigestive tract mucosa, occurring frequently in the larynx and hypopharynx. SPN is a low-grade malignancy of the pancreas, affecting primarily young females. Case report. We present the case of a 27 year-old woman, who was incidentally diagnosed with pancreatic mass during workup of a previously diagnosed PSCC. The patient was further addressed for endoscopic-ultrasound (EUS)-guided sampling by means of fine-needle aspiration (FNA), in order to achieve differential diagnosis. The EUS identified in the neck and body of the pancreas an encapsulated heterogeneous tumor, with solid and cystic components, and mixed elastography pattern. EUS-FNA was performed and the immunochemistry analysis of the specimens confirmed the diagnosis of solid pseudopapillary neoplasm. The patient underwent distal pancreatectomy followed by surgical resection of the oral PSCC without any complications. Two years after, she is free of symptoms or recurrence signs. Conclusion. Surgical resection of both tumors alongside with proper follow-up represent the mainstay of the treatment, providing long-term survival.
Keywords:- endoscopic ultrasound
- fine-needle aspiration
- immunohistochemistry
- pancreatectomy
- pseudopapillary tumor