Objectives: To assess the antibacterial effect of Pistacia atlantica (P. atlantica) subsp. (Kurdica) extract encapsulated in niosomes on Streptococcus mutans (S. mutans). Materials and methods: In this in vitro experimental study, different concentrations of span and tween were used to synthesize different formulations of P. atlantica extract encapsulated in niosomes. The physical and chemical properties of the synthesized niosomes were evaluated by scanning electron microscopy (SEM) and digital light scattering Zetasizer. The efficiency and release profile were also evaluated. The antibacterial effects of the synthesized niosomes with 7.8 to 1000 µg/mL concentrations were evaluated by the microtiter plate method. Results and discussion: The optimally synthesized niosomes measured 129.7 nm in size, and showed 90.62% containment. Nano-niosomes had a unilayer spherical structure. Niosomes containing P. atlantica extract showed more significant antibacterial effects against S. mutans than the free extract. Conclusions: Niosomes containing P. atlantica extract may serve as a suitable nano-carrier for antibacterial activity against S. mutans.
Keywords:- anti-infective agents
- niosome
- Streptococcus mutans