Helicobacter pylori infects 50% of the worldwide population. The vast majority of H.pylori infections are found in developing countries. The bacterial infection triggers an inflammatory response manifested in a series of intermediary stages for precancerous lesions (gastritis, atrophy, intestinal metaplasia and displasia). Approximately 10% of the infected people develop severe gastric lesions, 1-3% of the cases develop into gastric cancer and 0.1% – mucosa-associated lymphoid tissue (MALT). The primary phases of H.pylori infection, such as adhesion, invasion of gastric epithelium cells, and activation of intracellular routes up to epigenetic modifications are important for describing the molecular mechanisms of H. pylori pathogenesis
Keywords:- Helicobacter pylori
- molecular bases
- molecular mechanisms.