Medical dentistry continuously develops, in harmony with the information torrent that flows from the fundamental and clinical sciences and that models all things related to the medical field: obsolete things are eliminated, things that can still be applied are updated and new and necessary things are implemented. Scientific research changed our perceptions, our way of thinking and the attitude towards today and tomorrow. Minimally invasive dentistry (MID) coincided with the era of molecular medicine, which supports the quality increase of medical care, inclusive the preclinical identification of the predisposition to illness, preventive interventions, new diagnosis and treatment techniques and new biomaterials for the repair and regeneration of oral and dental tissues and craniofacial structures.