Introduction: Periodontitis is a chronic inflammatory disease characterised by inflammation of the tooth supporting tissue. The most common neurodegenerative disease that accounts for 80% of dementia, frequently encountered between elderly people, is Alzheimer. The aim of the current study was to identify the link between Alzheimer’s disease and periodontitis, with the existing biomarkers and genes that overlap each other through the cellular degenerative pathway. Materials and Methods: Differentially expressed genes (DEGs) of periodontitis and Alzheimer’s disease were identified from the datasets retrieved from the Gene Expression Omnibus database. The network was constructed by merging DEGs, and the interconnecting genes were identified and ranked using GeneMANIA. To delineate the biological implication of the significant gene associated with this interactome, the gene enrichment analysis for Gene Ontology (GO) terms was performed using the Enricher database. Results and discussion: The results of the study, presented in the form of graph and network or map format, enumerate the top 10 hub genes of both diseases and also the pathway that correlates with them. The presenilin pathway is found to be common in both periodontitis and Alzheimer’s disease. Previous articles have suggested that the deficiency of presenilin causes a series of biochemical alterations, including neuronal atrophy, astrogliosis, caspase-3-mediated apoptosis and hyperphosphorylation. Conclusions: The current study shows that presenilin pathway activation shows positive gene-gene interaction between Alzheimer’s disease and periodontitis through the presence of the above-idenitfied top 5 hub genes.
Keywords:- Alzheimer’s disease
- gene
- interactome
- periodontitis