Oral microbiota, comprising a complex community of microorganisms, is crucial in maintaining oral and systemic health. Recent research highlights the significant interplay between oral microbial dysbiosis and various systemic conditions, emphasizing the concept of an „oral-systemic link”. The present review explores the connections between oral microbiota and systemic diseases, including cardiovascular diseases, diabetes mellitus, autoimmune disorders, neurodegenerative conditions, and pregnancy complications.Key pathogenic species such as
Porphyromonas gingivalis and Fusobacterium nucleatum have been implicated in promoting systemic inflammation, bacterial dissemination, and immune dysregulation. We also discuss the bidirectional relationship between oral health and systemic diseases, exemplified by the impact of periodontitis on glycemic control in diabetes. Preventive strategies, including oral hygiene, probiotics, and advancements in microbiome monitoring, hold promise for mitigating systemic risks associated with oral dysbiosis.
This comprehensive review aims to elucidate the mechanisms connecting oral microbiota with systemic diseases, address current knowledge gaps, and propose future directions for research and clinical practice. Understanding these interactions is essential for developing integrative healthcare approaches to improve both oral and systemic health outcomes.
- dentistry
- ORAL MICROBIOTA
- systemic diseases