Antioxidants have gained interest in dentistry due to their ability to neutralize free radicals generated during clinical procedures and to protect oral tissues against oxidative stress. Their use is relevant in several areas: restoration of bond strength after bleaching or endodontic irrigation with oxidizing agents, dentine biomodification by collagen stabilization and metalloproteinase inhibition, and control of inflammation and bacterial biofilm in periodontal disease and caries. Current evidence supports the clinical efficacy of sodium ascorbate for immediate restoration of post‑bleaching bond, as well as the potential of polyphenols (proanthocyanidins, catechins, resveratrol) as adjuvants in adhesion, caries prevention, and periodontology. However, variability in protocols and the lack of long‑term clinical trials limit their inclusion in standardized guidelines. This article reviews the mechanisms, applications, and clinical perspectives of antioxidants in dentistry